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Please use a personal access token instead. Is the docker daemon running? Flask — Environment Can’t bind to ‘ngModel’ since it isn’t a known property of ‘input’ activate python virtualenv in cmd Can’t bind to ‘ngModal’ since it isn’t a known property of ‘input’. We next consider some common potential pitfalls on the path to diagnosis. The patient with comorbidities Interpretation of apparent language deficits should be cautious in older patients with a history of developmental dyslexia or longstanding peripheral hearing loss, especially when the recent symptoms target phonology or articulation and if additional cognitive involvement is subtle.
An outline of management Patients with PPA generally live for a number of years following diagnosis, with evolving deficits and specific needs at each stage of the illness. Non-pharmacological strategies Management begins with diagnosis; this is often delayed due to the lack of experience with these conditions in the wider medical community and the value of a clear explanation for patients and families should never be underestimated.
Pharmacological interventions There are currently no disease modifying treatments for PPA and evidence for efficacy of symptomatic treatments is scant. Conclusions and future directions Recognition of the major PPA syndromes has transformed our understanding of the language system and given us a new picture of selective neural vulnerability in degenerative brain disease.
Electronic supplementary material Below is the link to the electronic supplementary material. Supplementary material 1 MP3 kb 3.
Supplementary material 2 MP3 kb audio file. Supplementary material 3 MP3 kb 1. Supplementary material 4 MP3 kb 1. Compliance with ethical standards Conflicts of interest The authors declare that they have no conflicts of interest. Footnotes Charles R. Contributor Information Charles R. References 1. Grossman M. Primary progressive aphasia: clinicopathological correlations. Nat Rev Neurol. Primary progressive aphasia and the evolving neurology of the language network.
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Quantitative application of the primary progressive aphasia consensus criteria. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.
Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia. Connected speech production in three variants of primary progressive aphasia. Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia. J Neuroling. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Apraxia in progressive nonfluent aphasia. Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech.
The evolution of primary progressive apraxia of speech. Nonfluent variant primary progressive aphasia: a distinctive clinico-anatomical syndrome. Can MRI visual assessment differentiate the variants of primary progressive aphasia? Progressive affective aprosodia and prosoplegia. Right hemispheric dysfunction in a case of pure progressive aphemia: fusion of multimodal neuroimaging.
Psychiatry Res. Progressive associative phonagnosia: a neuropsychological analysis. Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. J Neurol Sci. Co-occurrence of language and behavioural change in frontotemporal lobar degeneration.
Dem Ger Cog Dis. Extrapyramidal signs in the primary progressive aphasias. Parkinsonian motor features distinguish the agrammatic from logopenic variant of primary progressive aphasia. Park Rel Dis. New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications. Aphasic variant of Alzheimer disease: clinical, anatomic, and genetic features.
Typical and atypical pathology in primary progressive aphasia variants. Clinical comparison of progressive aphasia associated with Alzheimer versus FTD-spectrum pathology. The heritability and genetics of frontotemporal lobar degeneration.
A longitudinal linguistic analysis of written text production in a case of semantic variant primary progressive aphasia. Hodges JR, Patterson K. Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol. Non-verbal sound processing in the primary progressive aphasias. The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. Flavour identification in frontotemporal lobar degeneration.
The association between semantic dementia and surface dyslexia in Japanese. J Cogn Neurosci. Generalization and differentiation in semantic memory: insights from semantic dementia. Ann N Y Acad Sci. Structure and deterioration of semantic memory: a neuropsychological and computational investigation.
Psychol Rev. The neural and computational bases of semantic cognition. Nat Rev Neurosci. Tracking progression in frontotemporal lobar degeneration: serial MRI in semantic dementia. On the right side? A longitudinal study of left- versus right-lateralized semantic dementia. The clinical profile of right temporal lobe atrophy.
Distinct behavioural profiles in frontotemporal dementia and semantic dementia. When one loses empathy. J Ger Psychiatry Neurol. Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cog Behav Neurol. Emotional caricatures in frontotemporal dementia. Altered sense of humor in dementia. J Alzheimers Dis. Pain and temperature processing in dementia: a clinical and neuroanatomical analysis.
Auditory hedonic phenotypes in dementia: a behavioural and neuroanatomical analysis. Dement Geriatr Cogn Disord. Impaired interoceptive accuracy in semantic variant primary progressive aphasia. Front Neurol. Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia. Corticospinal tract degeneration associated with TDP type C pathology and semantic dementia. Semantic and nonfluent aphasic variants, secondarily associated with amyotrophic lateral sclerosis, are predominant frontotemporal lobar degeneration phenotypes in TBK1 carriers.
Alz Dem. Neuropsychological profiles differ among the three variants of primary progressive aphasia. Memory and emotion processing performance contributes to the diagnosis of non-semantic primary progressive aphasia syndromes. J Alz Dis. Converging language streams in the human temporal lobe. J Neurosci. The logopenic variant of primary progressive aphasia.
Curr Opin Neurol. Initial neuropsychological profile of a series of 20 patients with logopenic variant of primary progressive aphasia. Is the logopenic-variant of primary progressive aphasia a unitary disorder?